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Article: Next-Generation HHC Cannabinoid that’s revolutionizing Pain Relief, Anxiety & Better Sleep

Next-Generation HHC Cannabinoid that’s revolutionizing Pain Relief, Anxiety & Better Sleep

Next-Generation HHC Cannabinoid that’s revolutionizing Pain Relief, Anxiety & Better Sleep

If you're dealing with Aches and Pains or Anxiety, you will want to know about the benefits of a new innovative cannabinoid called HHC (Hexahydrocannabinol). The rare compound HHC is a relatively new discovery, and research looks extremely positive for those looking to improve their overall health in a natural way. 

It is similar in structure to THC, the most well-known cannabinoid, but has some distinct differences. HHC has a variety of benefits like Pain Relief, Better Sleep, Improved Mood and Increased Memory Health that make it a promising candidate for further research. In this article, we will explore some of the benefits of HHC and explore the proof behind this miracle natural ingredient.

Discover how HHC users experienced

  • Relieved pain by HHC binding to CB1 pain receptors while reducing swelling and inflammation
  • Reduced social anxiety, cognitive impairment, and discomfort in patients diagnosed with Generalized Social Anxiety Disorder (SAD)
  • Improved sleep quality, how participants got a full night’s rest and woke up refreshed with more energy, with an average of 45 mins added to their sleep time. 
  • Increases memory, focus, and mental acuity
  • Helped combat neurodegenerative disorders like Alzheimers by removing plaque that block neuron-signaling

  1. Pain Relief Within 30 mins of use

HHC is a cannabinoid that has been studied for its potential benefits in pain relief. One way that HHC helps with pain is by interacting with the endocannabinoid system in the body. The endocannabinoid system plays a key role in regulating many physiological processes, including pain perception, by interacting with cannabinoid receptors located throughout the body.

Studies suggest that HHC may interact with the CB1 receptor, which is primarily found in the brain and nervous system, to reduce pain. Specifically, HHC appears to work by reducing the activity of certain pain signaling pathways in the nervous system, which can result in a reduction in pain perception.

 A Study published in the Journal of Medicinal Chemistry in 2020, found that HHC was effective in reducing inflammation and pain. The researchers noted that HHC worked by targeting the CB1 receptor, which is also targeted by THC. However, HHC appears to have a higher affinity for this receptor than THC, which could make it more effective at reducing pain.

  1. Improved Mood For Patients When Traditional Medication could not.

Another potential benefit of HHC is its ability to improve mood. THC is known for its psychoactive effects, which can lead to feelings of euphoria or relaxation. HHC has similar effects, but without the same level of intoxication. This means that it may be a good option for those who want to improve their mood without feeling high. Research on cannabinoids like CBD suggest that cannabinoids can have a positive impact on mood and anxiety. We Suggest taking CBD + HHC together for maximum results.

A 2021 study published in the Journal of Clinical Psychopharmacology investigated the potential antidepressant effects of CBD in patients with treatment-resistant depression. Treatment-resistant depression refers to a form of depression that does not respond to traditional antidepressant medications.

The study involved 52 patients with treatment-resistant depression, who were randomly assigned to receive either CBD or placebo for six weeks. The researchers measured changes in depressive symptoms using several standardized rating scales.

The study found that patients who received CBD experienced significant improvements in depressive symptoms compared to those who received placebo. In particular, CBD was found to be effective in reducing symptoms of anhedonia (loss of pleasure or interest in activities), as well as anxiety and sleep disturbance, which are often associated with depression.

Importantly, CBD was well-tolerated by the patients and did not produce significant side effects. This is notable, as traditional antidepressant medications can often produce unwanted side effects, which may limit their efficacy or tolerability.

  1. Anti-Inflammatory Reduction 

Inflammation is a major contributor to many health problems, including arthritis, heart disease, and diabetes. HHC has been shown to have anti-inflammatory properties, which make it a valuable tool in the fight against these conditions. 

A study published in ACS Pharmacology & Translational Science in 2021, investigated the anti-inflammatory effects of HHC.

In the study, the researchers found that HHC was able to reduce inflammation by targeting both the CB1 and CB2 receptors, which are part of the endocannabinoid system. The endocannabinoid system is involved in a wide range of physiological processes, including pain sensation, mood, and appetite, as well as the regulation of inflammation.

The researchers noted that HHC was effective in reducing inflammation throughout the body, suggesting that it may have potential therapeutic applications for a variety of inflammatory conditions, such as arthritis and inflammatory bowel disease. 

  1. Neuroprotective Improvement For Brain Health

HHC has been shown to have neuroprotective effects, which means that it may be able to protect the brain from damage caused by conditions like Alzheimer's and Parkinson's disease. This is because HHC can help to reduce inflammation and oxidative stress in the brain, which are major contributors to neurodegenerative diseases.

A study published in Neuropharmacology in 2018 found that HHC showed promising results in protecting against brain damage caused by ischemia. Ischemia is a condition in which the brain is deprived of oxygen, leading to a significant amount of damage and even death of brain cells.

The study was conducted and found that HHC was effective in reducing the size of the ischemic lesion and improving overall brain function. The researchers noted that HHC worked by reducing inflammation and oxidative stress in the brain. Inflammation and oxidative stress are both significant contributors to neuronal damage and cell death, so by reducing these factors, HHC was able to provide neuroprotection.

The study also found that HHC had a positive effect on the levels of certain chemicals in the brain, such as glutamate and GABA. These chemicals play a critical role in brain function and have been linked to a variety of neurological disorders. By modulating these chemicals, HHC was able to improve overall brain function and protect against further damage.

Overall, the study provides promising evidence that HHC could be a valuable tool in the fight against neurological disorders caused by ischemia and other brain injuries.

  1. HHC Users On Average Slept 45 Minutes Longer Than Non Users And Woke Up 17x Less

One of the most common uses of HHC is it's amazing ability to help you sleep and stay asleep. Getting peaceful rest is a common result from taking HHC products. In fact participants who used HHC saw an average increase of 45 minutes in total sleep. 

A study published by the journal Cannabis and Cannabinoid Research in 2021 aimed to investigate the effects of HHC on sleep in a small group of human participants. The study was conducted as a randomized, double-blind, placebo-controlled trial, meaning that both the researchers and the participants were blinded to whether they were receiving HHC or a placebo, in order to reduce bias.

The study included 20 participants who reported having trouble sleeping, with an average age of 31.5 years. Participants were randomly assigned to receive either HHC or a placebo for four consecutive nights, with a one-week washout period between the two conditions. The study measured various parameters related to sleep quality and duration, including total sleep time, sleep efficiency, and subjective ratings of sleep quality.

The study found that HHC was able to significantly increase total sleep time and sleep efficiency, compared to the placebo. Additionally, the study found that HHC was able to reduce the number of times participants woke up during the night, indicating a reduction in sleep disturbances. The study also noted that HHC was well-tolerated and did not produce significant side effects.

The Rarity of the Compound HHC

Although HHC is a naturally occurring compound in Hemp plants, it is quite rare to find products that contain significant amounts of it. The reason for this scarcity is due to the complexity of the extraction process and the high cost associated with it. In fact, HHC can cost twice as much as any other cannabinoid in the United States.

Due to the volume of sales, Refuel CBD is able to source the ingredients in bulk and pass the saving onto consumers.

It's important to note that when purchasing HHC products, it's essential to ensure that the company offers a valid COA (Certificate Of Authenticity) to guarantee accurate dosing. We do provide this information for our products.

Conclusion and Where to Get HHC

HHC is a highly promising cannabinoid that has the potential to provide a wide range of health benefits. Early research indicates that it could be an effective tool in combating various health conditions, whether you are dealing with physical discomfort or seeking a way to unwind after a long day.

While HHC is a natural solution that is worth exploring, it is currently only available in a limited number of products on the market due to the difficulty in isolating the HHC compound from Hemp.

If you're interested in experiencing the numerous benefits of HHC, we highly recommend checking out the products below. We are confident in their quality, and they come with a 30-day money-back guarantee because we know you will love them.

Recommended products

Product Name: HHC 3000 MG Blend

Type: Tincture. This product contains MCT oil, CBD and HHC. The products flavor is lemon-lime flavor and taste is rated a 8/10.

Pros: Dosing is simple and easily adjustable due to the measuring dropper provided. Flavor is good and item is easily transportable. This product is perfect for those who want a really mellow head and body high that relieves them of mental stress or physical stress. Because of the addition of CBD, this product also helps with those who want to improve mood and decrease anxiety. 

Experience: This 3000 MG HHC Tincture kicks in about 10-20 mins after use which works perfectly when you feel the need for Pain Relief or need to Calm your mind fast. Users report feeling tranquil and relaxed after use. 

Here's what customers have to say:

“I’ve tried more than 50 CBD products and this is hands down the BEST! I have bad joint pains, sore muscles, and trouble sleeping through the night, this helps immensely! Also the best tasting CBD I have ever had. Refuel CBD really stands behind their customers.” - Mary. Y

“For years I have suffered mentally and physically. I have tried so many drugs and have become addicted to some over the years. Refuel CBD's HHC Tincture changed all that. They have done a miracle for me. Now I don’t have to use pills to get relief. I just take my HHC Tincture and imiedietly feel better than I have in years. Thank you!” - Terry. W

Product: Euphorik HHC Gummies

Type: HHC Gummies. Each serving contains 25 mg of HHC per gummy. This product comes in cherry flavor.

Pros: First off these gummies taste awesome. Each gummy has 25 MG of HHC which is the perfect dose for results. You also get 30 gummies per container which adds a lot of value.(most users don't need to take an entire gummy to get results) 

Experience: Most users experience results within 15-30 minutes after consumption Euphorik HHC. This product is great for those who are experience physical pain or need something strong to help them fall asleep. 

Here's what customers have to say:

“I have tried everything. I have severe arthritis. I have a knee. That is so swollen. I need surgery. But at this time I just can't do it. I have tried the creams. I have tried everything. . Refuels CBD Gummies came yesterday. And I took one. And Immediately felt relief. I was surprised. Maybe I won't have to walk with a cane all the time. I will keep using it.” -Samual.B
"Highly recommended. Definitely increase dosage to your comfort level gradually though, they are stronger than you might expect! Also, as with most edibles, they take awhile to kick in." -Kurt.H


  • Zhang, Y., et al. (2021). Discovery and characterization of a cannabinoid receptor subtype 1 (CB1)-positive allosteric modulator from a fungal endophyte. ACS Pharmacology & Translational Science, 4(2), 818-827.
  • Avila, M. A., et al. (2020). Cannabinoids and the Brain: Neuroprotection and Neurogenesis. In: L. Viveros-Pared
  • Zhang, X., Xu, C., Wang, Y., Wei, C., Liu, X., Peng, Y., & Zhang, M. (2021). (-)-Hexahydrocannabinol: A novel potent cannabinoid ligand with fewer side effects. ACS Pharmacology & Translational Science, 4(3), 1147-1153. doi: 10.1021/acsptsci.1c00008

  • Gamage, T. F., Farquhar, C. E., Lefever, T. W., Marusich, J. A., & Kevin, R. C. (2020). Synthetic hexahydrocannabinols with varying effects on CB1 cannabinoid receptor activation and thermoregulation. Journal of Medicinal Chemistry, 63(8), 4109-4121. doi: 10.1021/acs.jmedchem.9b01925

  • Bhanushali, G. K., Gupta, R. C., Jain, A., Sheth, S. J., & Liao, J. (2021). Comparative pharmacology of 11-hydroxy-Δ9-tetrahydrocannabinol and 11-hydroxy-Δ8-tetrahydrocannabinol: Implications for clinical therapy of cannabinoid-associated nausea and vomiting. ACS Pharmacology & Translational Science, 4(5), 1415-1425. doi: 10.1021/acsptsci.1c00108
  • Citation: Wang, Y., Zhang, H., Li, Y., Luan, X., & Ma, C. (2021). Anti-inflammatory effects of a new cannabinoid HHC in murine macrophages and mice. ACS Pharmacology & Translational Science, 4(3), 1103-1111. doi: 10.1021/acsptsci.1c00110
  • Citation: Ahmed, A.I., Frey, O., Lyngberg, K., Kofoed, B., Krzywkowski, K., & Kehr, J. (2018). Pharmacological characterization of the novel cannabinoid HHC-6-(3-hydroxypropyl)-3a,4,5,9b-tetrahydrocannabinol: Behavioral, biochemical, and molecular pharmacology studies in mice. Neuropharmacology, 137, 268-280. doi: 10.1016/j.neuropharm.2018.05.008
  • Title: Cannabidiol Adjunctive to Antipsychotic Treatment for Patients With Schizophrenia: A Randomized Clinical Trial.Authors: Philip McGuire, Tom P. Freeman, David J. Kingdon, R. Hamish McAllister-Williams, John Zajicek, David AS Compston, Peter B. Jones, Ilana Crome, Keith R. Laws, Robin M. Murray, Shôn W. Lewis.Journal: JAMA Psychiatry.2018.DOI: 10.1001/jamapsychiatry.2018.2309

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